KMID : 0892920220310050299
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Experimental Neurobiology 2022 Volume.31 No. 5 p.299 ~ p.306
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Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity
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Han Jae-Joon
Noh Tae-Soo Suh Myung-Whan Kim Seung-Ha Kim Doo-Hee Kim Sang-Jeong Oh Seung-Ha
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Abstract
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We aimed to evaluate structural dynamic changes of neurons in the auditory cortex after visual deprivation. We longitudinally tracked dendritic spines for 3 weeks after visual deprivation in vivo using a two-photon microscope. GFP-labeled dendritic spines in the auditory cortex were serially followed after bilateral enucleation. The turnover rate, density, and size of the spines in the dendrites were evaluated 1, 2, and 3 weeks after visual deprivation. The turnover rate of the dendritic spines in the auditory cortex increased at 1 week (20.1¡¾7.3%) after bilateral enucleation compared to baseline (12.5¡¾7.9%); the increase persisted for up to 3 weeks (20.9¡¾11.0%). The spine loss rate was slightly higher than the spine gain rate. The average spine density (number of spines per 1 ¥ìm of dendrite) was significantly lower at 2 weeks (2W; 0.22¡¾0.06 1/¥ìm) and 3 W (0.22¡¾0.08 1/¥ìm) post-nucleation compared to baseline (0.026¡¾0.09 1/¥ìm). We evaluated the change of synaptic strength in the stable spines at each time point. The normalized spine size in the auditory cortex was significantly increased after bilateral blindness at 1 W postoperatively (1.36¡¾0.92), 2 W postoperatively (1.40¡¾1.18), and 3 W postoperatively (1.36¡¾0.88) compared to baseline. Sensory deprivation resulted in remodeling of the neural circuitry in the spared cortex, via cross-modal plasticity in the direction of partial breakdown of synapses, and enhanced strength of the remaining synapses.
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KEYWORD
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Auditory cortex, Cross-modal plasticity, Two-photon, Sensory deprivation
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